Showing posts with label Cancer Treatment. Show all posts
Showing posts with label Cancer Treatment. Show all posts

Thursday, September 26, 2019

Researchers develop new framework for nanoantenna light absorption

Researchers develop a new framework for nanoantenna light absorption:



Harnessing light's energy into nanoscale volumes require novel engineering approaches to overcome the fundamental barrier is known as the "diffraction limit." However, University of Illinois researchers have breached this barrier by developing nanoantennas that pack the energy captured from light sources, such as LEDs, into particles with nanometer-scale diameters, making it possible to detect individual biomolecules, catalyze chemical reactions and generate photons with desirable properties for quantum computing.
The results, which have a broad array of applications that may include better cancer diagnostic tools, To create a device capable of overcoming the diffraction limit, graduate student Qinglan Huang and her adviser, Holonyak Lab Director Brian T. Cunningham, a Donald Biggar Willett Professor in Engineering, coupled photonic crystals with a plasmonic nanoantenna, an innovative approach in the field. The photonic crystals serve as light receivers and focus the energy into an electromagnetic field that is hundreds of times greater than that received from the original light source, such as an LED or laser. The nanoantennas, when "tuned" to the same wavelength, absorb the energy from the electromagnetic field and concentrate the energy into a smaller volume that is yet another two orders of magnitude of greater intensity. The energy feedback between the photonic crystal and the nanoantenna, called "resonant hybrid coupling" can be observed by its effects on the reflected and the transmitted light spectrum.
To achieve this, the team carefully controlled the density of the nanoantennas to maximize their energy collection efficiency. They also developed a method that allowed the nanoantennas to be distributed uniformly across the photonic crystal surface and tuned the photonic crystal's optical resonating wavelength to match the absorption wavelength of the nanoantennas. In addition to changing how researchers can work with light, this new coupling method has the potential to change how and when cancer is diagnosed. One application is to use a gold nanoparticle, not much larger than biomolecules such as DNA, as the nanoantenna. In this case, the feedback provides a way to identify a biomarker unique to a certain type of cancer cell, and the group now linking the resonant hybrid coupling technique to novel biochemistry methods to detect cancer-specific RNA and DNA molecules with single-molecule precision. The next steps of this research involve delving into the potential applications of this new process.

Source Credit: Nano Magazine

Monday, September 16, 2019

Tiny extracts of a precious metal used widely in industry could play a vital role in new cancer therapies

Tiny extracts of a precious metal used widely in industry could play a vital role in new cancer therapies:

Researchers have found a way to dispatch minute fragments of palladium—a key component in motor manufacture, electronics and the oil industry—inside cancerous cells. Scientists have long known that the metal, used in catalytic converters to detoxify exhaust, could be used to aid cancer treatment but, until now, have been unable to deliver it to affected areas.
A molecular shuttle system that targets specific cancer cells has been created by a team at the University of Edinburgh and the Universidad de Zaragoza in Spain. The new method, which exploits palladium's ability to accelerate—or catalyse—chemical reactions, mimics the process some viruses use to cross cell membranes and spread infection. The team has used bubble-like pouches that resemble the biological carriers known as exosomes, which can transport essential proteins and genetic material between cells. These exosomes exit and enter cells, dump their content, and influence how the cells behave.
This targeted transport system, which is also exploited by some viruses to spread infection to other cells and tissues, inspired the team to investigate their use as shuttles of therapeutics.The researchers have now shown that this complex communication network can be hijacked. The team created exosomes derived from lung cancer cells and cells associated with glioma—a tumour that occurs in the brain and spinal cord—and loaded them with palladium catalysts. These artificial exosomes act as Trojan horses, taking the catalysts—which work in tandem with an existing cancer drug- straight to primary tumours and metastatic cells.
Source: Nanomagazine